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Did you start your new job today?”“I did,” she said.“Good. Then you’re buying!” I chuckled.“I guess chivalry is dead,” she teased.“Not at all. I’ll hold the door, pull out your chair, be polite, all that kind of stuff. You’re still paying!”“See you tomorrow at 11:45 at that diner across from the hospital.”“You got it!” I said.I had a nice lunch with Kimmy, which included a passionate lovemaking session, and spent the afternoon working on the conversion project. That evening, after dinner, we went to karate as usual and I was surprised to see Sensei Jim at the dojo.“Are you free for lunch on Sunday? That’s when our next ISKC meeting is being held. I meant to tell you about it before Christmas, but with all the stuff going on with Jessica I wanted to wait, and then it slipped my mind.”“I think that will work. I’ll check with Kara, but it shouldn’t be an issue. Where?”“We meet at Lou Malnati’s. Do you know where that is?”“Sure. Just north of the Loop on Wells.”“11:30am on Sunday.”“I’ll. " Go on," Mr Thwaites encouraged."Well, the DNA isn't necessarily being damaged by the virus; it's just thatsome genes have been deactivated, or a dormant gene--or genes--unexpectedlyactivated by the virus. By reacting to some signal, or impulse when thevirus penetrates the cell's nucleus. And it can work the other way. Cancershave been reversed in mice by a virus. A retrovirus to be exact." This is very basic," Mr Thwaites said impatiently. "At least, it's basicfor undergraduates," he added more thoughtfully. "Go on," Mr Thwaites urged.Mandy furrowed her brow in concentration. "The virus itself stores itsnucleic acid, in the form of a genome and serves as a means of delivery ofthat genome into cells it targets as an obligate parasite, and constitutesthe infection. Once in the host's cell, the RNA strands undergo reversetranscription in the cytosol--that's, like, the internal fluid in a cell--andare integrated into the host's genome, at which point the retroviral DNA isreferred to as.
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